From Global to Local Alignment
Let’s observe global alignment, local alignment, their problems, and some limitations of global alignment.
Global alignment
You should now be ready to modify the alignment graph to solve a generalized form of the alignment problem that takes a scoring matrix as input.
Global Alignment Problem
Problem overview:
Find the highest-scoring alignment of two strings as defined by a scoring matrix.
Input: Two strings and a scoring matrix Score.
Output: An alignment of the strings whose alignment score (as defined by Score) is maximized among all possible alignments of the strings.
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