From Protein Comparison to Non-Ribosomal Code
Let’s see how Marahiel aligned the A-domains to discover the non-ribosomal signatures.
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Inferring the non-ribosomal code
Fortunately, Marahiel already knew the amino acid sequences of some A-domains, along with the amino acids that they add to the growing peptide. Below are three of these A-domains (taken from three different bacteria), which code for aspartic acid (Asp), ornithine (Orn), and valine (Val), respectively. In the interest of space, we’ll show you only short fragments taken from the three A-domains.
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